Lipid-induced cell stress and insulin resistance
نویسندگان
چکیده
منابع مشابه
Lipid-induced hepatic insulin resistance
principal function of insulin in the liver is to suppress glucose production when blood glucose concentrations increase. This process is impaired in hepatic insulin resistance and contributes to postprandial hyperglycemia. The development of hepatic insulin resistance is very closely linked to non alcoholic fatty liver disease (NAFLD), and is a major factor in the pathogenesis of type 2 diabete...
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Leptin-induced increases in insulin sensitivity are well established and may be related to the effects of leptin on lipid metabolism. However, the effects of leptin on the levels of lipid metabolites implicated in pathogenesis of insulin resistance and the effects of leptin on lipid-induced insulin resistance are unknown. The current study addressed in rats the effects of hyperleptinemia (HL) o...
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Additional information for this article can be found in an online appendix at http://diabetes.diabetesjournals.org This is an uncopyedited electronic version of an article accepted for publication in Diabetes. The American Diabetes Association, publisher of Diabetes, is not responsible for any errors or omissions in this version of the manuscript or any version derived from it by third parties....
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Lipid abnormalities such as obesity, increased circulating free fatty acid levels, and excess intramyocellular lipid accumulation are frequently associated with insulin resistance. These observations have prompted investigators to speculate that the accumulation of lipids in tissues not suited for fat storage (e.g., skeletal muscle and liver) is an underlying component of insulin resistance and...
متن کاملOxidative Stress and Insulin Resistance
OBJECTIVE Although cumulative evidence suggests that increased oxidative stress may lead to insulin resistance in vivo or in vitro, community-based studies are scarce. This study examined the longitudinal relationships of oxidative stress biomarkers with the development of insulin resistance and whether these relationships were independent of obesity in nondiabetic young adults. RESEARCH DESI...
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ژورنال
عنوان ژورنال: Scandinavian Journal of Food and Nutrition
سال: 2006
ISSN: 1748-2976,1748-2984
DOI: 10.1080/17482970601066132